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KMID : 0861020200350030017
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Korea Journal of Herbology
2020 Volume.35 No. 3 p.17 ~ p.24
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Gastroprotective Activity of Curcumae Longae Rhizoma against Gastric Ulcer in Mice
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Oh Min-Hyuck
Kim Min-Ju
Shin Mi-Rae
Park Hae-Jin
Seo Bu-Il
Roh Seong-Soo
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Abstract
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Objectives : The objective of this study was to evaluate the gastric protective effect of Curcuma Longae Rhizoma (CLR) in 150 mM HCl/60% ethanol induced gastric ulcer (GU) in mice.
Methods : Forty ICR mice were divided into five groups (n=8/Group): Nor group; Normal, Veh group; GU control, SC group; GU + sucralfate 10 ㎎/㎏, CL; GU + CLR 30% ethanol extract 100 ㎎/㎏, CH group; GU + CLR 30% ethanol extract 200 ㎎/㎏. Then, mice were orally administered with 150 mM HCl/60% ethanol and caused GU. After 1 hr, mice were sacrificed, and blood and stomach tissue were collected.
Results : CLR showed significance scavenging effects in 1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2’-azinobis-3- ethyl-benzothiazoline-6-sulfonic acid (ABTS) radical scavenging activities (DPPH IC50; 78.18 ± 0.60 ㎍/㎖, ABTS IC50; 55.91 ± 1.86 ㎍/㎖). CLR significance reduce inflammatory-related factors such as cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β), and interleukin-6 (IL-6) via nuclear factor kappa B (NF-κB) inactivation. In addition, the activation of nuclear factor erythroid2-related factor 2 (Nrf2) significantly led to up-regulation of anti-oxidant enzymes including factors heme oxygenase-1 (HO-1), super oxide dismutase (SOD), and glutathione peroxidase-1/2 (GPx-1/2).
Conclusions : Our discovery provides that CLR possesses anti-oxidant and anti-inflammatory effects. Hence, CLR may ameliorate the development of gastric ulcer though the inhibition of NF-κB inflammatory pathway and the elevation of Nrf2 anti-oxidant pathway.
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KEYWORD
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Curcumae Longae Rhizoma, Gastric ulcer, anti-oxidant, anti-inflammatory
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